Autoimmune disease affecting multiple body systems is abbreviated as what?

• A. SLE
• B. Type 1 diabetes
• C. Psoriasis
• D. Myasthenia gravis

Answer: (A)

Systemic lupus erythematosus is the autoimmune disease that classically involves many body systems. In SLE, the immune system makes autoantibodies against nuclear components, forming immune complexes that can deposit in skin, joints, kidneys, brain, blood vessels, and other tissues. This leads to a wide range of features—from a malar facial rash and joint pain to kidney inflammation, anemia or other blood abnormalities, and neuropsychiatric symptoms. That broad, multi-organ involvement is what sets systemic lupus erythematosus apart.

In contrast, type 1 diabetes is primarily autoimmune destruction of pancreatic beta cells, leading to insulin deficiency and hyperglycemia with mainly endocrine consequences. Psoriasis is mainly an inflammatory skin disorder with systemic associations but classically limited to the skin. Myasthenia gravis targets the neuromuscular junction, causing muscle weakness, and is not a multi-system disease in the typical sense.